Ullmann-type reductive homo-coupling reactions at room temperature

The implementation of sustainable and environmentally friendly protocols is an emerging field of the chemical industry. The need for safe and reliable processes as the alternative of demanding, wasteful, toxic or hazardous methods is pointing towards a new paradigm in organic synthesis. Enabling technologies, like flow chemistry, especially continuous flow heterogeneous catalysis makes green and sustainable chemical procedures available.

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Using flow chemistry in agrochemical applications

The need for easy and fast high throughput screening tools to find target compounds which can be patented and produced in commercial scale is ever growing. Such a tool is flow chemistry, which is being employed in several chemical industries due to its benefits. In this application note we provide information from patents from major agrochemical companies, Syngenta and Dow Agrosciences, where flow chemistry was used for the synthesis of active compounds.

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Catalyst screening and profiling

ThalesNano is already well-known for its novel solutions in revolutionizing heterogeneous catalytic hydrogenations with its H-Cube® hydrogenator, while the expanded H-Cube series of fixed bed reactors offers a broad range of chemistry applications. With a wide portfolio of different catalysts available in our proprietary CatCart® catalyst cartridges ThalesNano is also heavily involved in the development, of novel catalysts, screening and profiling of catalysts.
In this application note we share the results of the optimization of the flow rate and temperature during the stereoselective hydrogenation of diphenyl acetyle. Furthermore, the longevity of the catalyst is also described, showing a slight increase in conversion and selective over 20 reactions.

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Gaseous reagent organic chemistry makes easy

The Gas Module works seamlessly with the H-Cube Pro allowing a further 13 gases to be used at up to 100 bar using the same touch screen intuitive controls. Reactions such as carbonylation or oxidation can now be performed on the H-Cube Pro at the same high pressure and ease of use, extending the reactor’s chemistry capacity significantly, as it is presented in this application note.

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Versatile chemistry examples performed on the Phoenix high temperature, high pressure flow reactor

The ability to explore wider chemistry space to discover new chemistry and compounds is becoming increasingly more critical as increased R&D costs go hand in hand with lower new registered molecules year on year. To achieve this, we, as chemists, must seek to expand the capabilities that we have in the lab in terms of temperature and pressure, but in a reliable and safe way. The Phoenix Flow Reactor is technology designed specifically for this process. With the ability to perform homogeneous and heterogeneous chemistry up to 450 °C and 200 bar, the Phoenix Flow Reactor is versatile enough to create new or improve on existing chemistry. In this application note, we demonstrate the flexibility of the Phoenix Flow Reactor by presenting various applications such as N-substitution, thermal Boc-removal, scalable Claisen-rearrangement and synthesis of soluble polyphosphide anions.

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